Effective September 5, 2026
Start with product identity
Know whether the product is natural leaf, a powder-filled capsule, a conventional botanical extract, a food or beverage, enhanced 7-OH, or a synthetic or semi-synthetic derivative. Read the complete label and match the batch number to a current COA. Avoid mitragynine pseudoindoxyl, MGM-15, MGM-16, similar synthetic or semi-synthetic compounds, and products with added or enhanced 7-OH.
Do not combine substances
Do not combine kratom with alcohol, opioids, benzodiazepines, sedatives, sleep medicines, cough or cold medicines, stimulants, or other psychoactive substances. Interactions are incompletely understood and may increase risk. Ask a clinician or pharmacist about your medicines, supplements, conditions, and complete substance-use history.
Pregnancy, breastfeeding, and health conditions
Do not use kratom during pregnancy or breastfeeding. People with medical or mental-health conditions, a history of substance-use problems, or prescription medicines should seek individualized professional guidance before considering any kratom product.
Frequency, tolerance, and dependence
Repeated use can lead to tolerance, dependence, and withdrawal symptoms. Pay attention to escalating use, difficulty cutting back, using more often than intended, or continuing despite harm. Do not drive, operate machinery, supervise children, or perform safety-sensitive tasks if impaired.
Labels, portions, and storage
Follow the product label and do not treat form names or strain colors as dosing guidance. Do not repeatedly add product to an unmeasured mixture. Keep original packaging and batch identity, secure every product away from children and pets, and label any prepared drink or food clearly for informed adult use only.
Know when to get urgent help
Call 911 if someone collapses, has a seizure, has trouble breathing, or cannot be awakened. In the United States, call Poison Control at 1-800-222-1222 or use webPOISONCONTROL. For treatment help, use FindTreatment.gov or call or text 988 during a mental-health or substance-use crisis.
Not medical advice
This page provides general safety information, not diagnosis, dosing, treatment, or personalized medical advice. A positive personal or historical account does not establish safety for another person.